Role of lubricin and boundary lubrication in the | GBS Bearing

Full-Length Recombinant Human Proteoglycan 4 Interacts with Hyaluronan to Provide Cartilage Boundary Lubrication | SpringerLi

Full-Length Recombinant Human Proteoglycan 4 Interacts with Hyaluronan to Provide Cartilage Boundary Lubrication Authors Authors and affiliations ...

Lubricin: New Promise for Joint-Preserving Therapy | Rheumatology Netwo

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci (2013) 110:5852-5857 23. Waller KA, Zhang LX, Fleming BC, Jay GD. Preventing friction-induced chondrocyte apoptosis: comparison of human synovial fluid ...

Lubricin is Required for the Structural Integrity and Post .

The Proteoglycan 4 (Prg4) product lubricin plays essential roles in boundary lubrication and movement in limb synovial joints, but its roles in temporomandibular joint (TMJ) are unclear. Thus, we characterized the TMJ phenotype in wild-type and Prg4 –/– mouse littermates over age. As early as 2 weeks of age, mutant mice exhibited hyperplasia in the glenoid fossa articular cartilage ...

Proteoglycan 4 - Wikiped

Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis.When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature).

Galectin-3 Binds to Lubricin and Reinforces the .

SCIENIIC REPORTS 243 DOI 1.13srep243 1 www.nature.comscientificreports Galectin-3 Binds to Lubricin and Reinforces the Lubricating Boundary Layer of Articular Cartilage Heidi L. Reesink1, Edward D ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the ...

The distribution of superficial zone protein (SZP .

The distribution of superficial zone protein (SZP)/lubricin/PRG4 and boundary mode frictional properties of the bovine diarthrodial joint Gordon Penga, Sean M. McNarya, Kyriacos A. Athanasioua,b, A. Hari Reddia,n a Lawrence Ellison Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California, Davis,

Regulation of lubricin for functional cartilage tissue regeneration: a review | Biomaterials Research | Full Te

The fundamental role of lubricin is lubrication of boundary surface of cartilage []. Hence, transmutation of lubricin metabolism would conspicuously influence joint performance. In fact, patients who suffer from osteoarthritis (OA), degenerative joint disease, or ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | PN

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

Proteoglycan 4 - Wikiped

Function Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP).

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | Request P

Request PDF on ResearchGate | Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and ...

The role of lubricin in the mechanical behavior of synovial fluid | G D Jay | Request P

Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA–protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

Arthritis Control through Dual Axis Lubricin Over .

This treatment paradigm builds on the role of interleukin-1 antagonist protein (IL-1Ra) as the gatekeeper for rampant IL-1 induced matrix catabolism, combined with the fundamental knowledge garnered from biophysical and functional lubricin and galectin studies that show lubricin supplementation can enhance boundary lubrication and limit the ...

Supramolecular synergy in the boundary lubrication of synovial joints | Nature Communicatio

with a very different role, to provide the boundary lubrication characteristic of healthy synovial joints: ... The role of lubricin in the mechanical behavior of synovial fluid. Proc. Natl Acad. Sci. USA 104, 6194–6199 (2007) . CAS PubMed Article 33. Linn, F . ...

The role of lubricin in the mechanical behavior of .

Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load. Individuals with genetic deficiency of lubricin develop precocious joint failure.

Boundary mode lubrication of articular cartilage by .

Lubrication of cartilage involves a variety of physical and chemical factors, including lubricin, a synovial glycoprotein that has been shown to be a boundary lubricant. It is unclear how lubricin boundary lubricates a wide range of bearings from tissue to artificial surfaces, and if the mechanism is the same for both soluble and bound lubricin.

The biology of Lubricin: Near frictionless joint motion - ScienceDire

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

National Academy of Sciences Contact Feedback Submit Subscribe Keyword, Author, or DOI GO Advanced Search ... number of apoptotic chondrocytes. These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival ...

The role of lubricin in the mechanical behavior of synovial fluid. | Sigma-Aldri

Abstract Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under ...

Proteoglycan 4 - Wikiped

Function Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP).

Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin - ScienceDire

Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin ... B.C. Fleming, M.L. Warman, G.D. JayRole of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Proc. Natl ...